Research
Interests
Research in my laboratory focuses on the causes of cardiovascular
disease, especially systemic hypertension. A major emphasis is on how
sympathetic nerves affect short-term and long-term regulation of the cardiovascular
system. We study both brain and peripheral autonomic mechanisms using
pharmacological tools in conscious rats and mice. A particular interest
is in how the hormones angiotensin II and endothelin influence sympathetic
nerve function. Recently we started a collaborative research effort with
several other MSU investigators to explore the differences in neurohormonal
control of arteries versus veins. The role of oxidative stress in modulating
neural and vascular function is a current emphasis. Our ultimate goal
is to develop new therapeutic approaches to cardiovascular disease by
targeting the sympathetic nerves innervating the veins.
Please feel free to contact me if you
have any questions about my research.
Selected
Publications
Search all publications in the NCBI Journal Database
King AJ, Fink GD.
Chronic Low-Dose Angiotensin II Infusion Increases Venomotor Tone by Neurogenic Mechanisms. Hypertension. 2006 Sep 25; [Epub ahead of print]
PMID: 17000931 [PubMed - as supplied by publisher]
Lau YE, Galligan JJ, Kreulen DL, Fink GD.
Activation of ETB receptors increases superoxide levels in sympathetic ganglia in vivo. Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R90-5. Epub 2005 Sep 22. PMID: 16179487 [PubMed - indexed for MEDLINE]
Wang H, Chen AF, Watts SW, Galligan JJ, Fink GD. Endothelin in the splanchnic vascular bed of DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H729-36. Epub 2004 Oct 7.
PMID: 15471983 [PubMed - indexed for MEDLINE]
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Gregory
D. Fink 