Research Interests
My
research program is focused on sex differences in the neural and endocrine
mechanisms controlling blood pressure in normal and sodium-dependent hypertensive
animals. In rat models, central nervous system mechanisms are studied
using microinjection and microdialysis techniques to understand the neurochemical
basis for changes in sympathoadrenal neural function. Peripheral hemodynamic
and neuroendocrine parameters are measured to determine the mechanisms
maintaining elevated blood pressure. In related studies, the genetic phenotypes
contributing to sodium-dependent hypertension are investigated in a pedigree
colony of baboons at Southwest Foundation for Biomedical Research in San
Antonio, Texas in which markers for hypertension have been demonstrated.
Genetically determined alterations in cell sodium regulation in animals
that are hypertensive is being investigated as a triggering factor in
the hypertensive process. By understanding the mechanisms contributing
to the long-term control of blood pressure, a greater understanding of
new, effective ways of treating chronic cardiovascular disease will be
gained.
Please
feel free to contact me if you have any questions about my research.
Selected Publications
Search all publications in the NCBI Journal Database
Ji, H., Pesce, C., Zheng, W., Kim, J., Zhang, Y., Menini, S., Haywood, J.R. and Sandberg, K.: Sex differences in renal injury and nitric oxide production in renal wrap hypertension. Amer. J. Physiol. 288(1): H43-H47, 2005.
Vitela, M., M. Herrera-Rosales, J.R. Haywood, and S.W. Mifflin. Baroreflex regulation of renal sympathetic nerve activity and heart rate in renal wrap hypertensive rats. Amer. J. Physiol. 288(4): R856-R862, 2005.
Brooks, V.L., Haywood, J.R. and Johnson, A.K.: Translation of salt retention to central acti-vation of the sympathetic nervous system in hypertension. Clin. Exp. Pharmacol. Physiol. 32(5-6): 426-432, 2005.
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Joseph
R. Haywood