Research
Interests
The
main focus of the laboratory is on neuroimmune-endocrine interactions.
We study the effects of bacterial lipopolysaccharides and cytokines on
brain neurotransmitter systems and how they affect the secretion of
hormones such as luteinizing hormone (LH). We also study the effects of chemicals
found in the environment and their potential to be endocrine disrupters.
For this purpose, we use Sprague-Dawley rats and a combination of techniques
such as push-pull perfusion, HPLC-EC, Palkovits’ microdissection
of the brain, PCR for detecting cytokines in specific areas of the brain,
SDS-PAGE with western blotting, RIAs, immunohistochemical localization
of various cytokine receptors etc.
Selected
Publications
Search all publications in the NCBI Journal Database
Sirivelu MP, MohanKumar SM, Wagner JG, Harkema JR, MohanKumar PS. Related Articles, Links Activation of the stress axis and neurochemical alterations in specific brain areas by concentrated ambient particle exposure with concomitant allergic airway disease. Environ Health Perspect. 2006 Jun;114(6):870-4.
MohanKumar SM, MohanKumar PS. Systemic Interleukin-1beta stimulates the simultaneous release of norepinephrine in the paraventricular nucleus and the median eminence. Brain Res Bull. 2005 May 15;65(5):451-6.
MohanKumar SM, Smith CL, MohanKumar PS. Related Articles, Links Central adaptation to chronic administration of interleukin-1beta (IL-1beta) in rats. Brain Res Bull. 2003 Nov 15;62(1):71-6.
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Sheba
M. J. MohanKumar