Greg Swain

 swain@chemistry.msu.edu

Research Interests

Research in our group is focused on gaining a better understanding of noradrenergic transmission in arteries and veins and how this signaling is altered in cardiovascular disease states, such as hypertension. The pathophysiological mechanisms of neural control in the vasculatureare being probed in vitro using various pharmacological agents along with continuous amperometry and video imaging. Microseparation techniques are also being employed to measure extracellular and circulating levels of norepinephrine and its metabolites in order to better understand how release, uptake and metabolism are altered in the disease state. In a new thrust in the group, the normal pathophysiology of enterochromaffin cells residing in the intestinal mucosal layer and their control of gastrointestinal function is being studied. To this end, continuous amperometry is being used along with various pharmacological agents to record real time release of 5-hydroxytryptamine (5-HT, serotonin). All of our work is performed collaboratively with researchers in the Departments of Physiology, Pharmacology and Toxicology, and Human Medicine.

Selected Publications

View http://www.chemistry.msu.edu/faculty/swain for the most current list of publications.

Search all publications in the NCBI Journal Database

Park J, J. Park, J. J. Galligan, G. D. Fink and G. M. Swain (2006) In vtro cntinuous aperometry with a diamond mcroelectrode cupled with video microscopy for simultaneously monitoring endogeneous norepinephrine and its effect on the contractile response of a rat mesenteric artery, Anal Chem 78:6756-6766.

Park J, Quaiserová-Mocko V, Pecková K, Galligan JJ, Fink GD and Swain GM (2006) Fabrication, characterization, and application of a diamond microelectrode for electrochemical measurement of norepinephrine release from the sympathetic nervous system. Diamond Relat Mater 15: 761-772.

Park J, Show Y, Quaiserova V, Galligan JJ, Fink GD and Swain GM (2005) Diamond microelectrodes for use in biological environments. J Electroanal Chem 583: 56-68.