Research Interests
I am investigating the function of endothelin receptors expressed in HEK 293 cells and mesenteric blood vessels and the molecular mechanisms by which endothelin receptors couple to other effector molecules including receptors and ion channels using pharmacological, biochemical, immunocytochemical, imaging and electrophysiological approaches. I focuses on the functional interaction between ETA and ETB receptors with implications for venous ET-1 reactivity in hypertension.
Selected Publications
Differential trafficking and desensitization of human ET(A) and ET(B) receptors expressed in HEK 293 cells. Dai X, Galligan JJ. Exp Biol Med. 2006 Jun;231(6):746-51.
Superoxide anion is elevated in sympathetic neurons in DOCA-salt hypertension via activation of NADPH oxidase. Dai X, Cao X, Kreulen DL. Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1019-26.
Increased O2*- production and upregulation of ETB receptors by sympathetic neurons in DOCA-salt hypertensive rats. Dai X, Galligan JJ, Watts SW, Fink GD, Kreulen DL. Hypertension. 2004 May;43(5):1048-54.
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Dai