 Hui Xu
M.D., 1983, Xinjiang Medical University, China.
Ph.D., 1999, Kagawa Medical University, Japan.
Lab Affiliation: Dr. J. Galligan
 xuhui2@msu.edu
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Research
Interests
My research focuses on cardiovascular pharmacology and physiology. A particular interest is in the hormonal and neuronal control of blood pressure and causes of high blood pressure or hypertension. The role of the sympathetic nervous system and endothelin in cardiovascular regulation are a particular focus, as is the relationship with oxidative stress. A recent interest is in understanding the mechanisms controlling the vascular function by interaction of vasoactivator receptor (ETA or adrenergic receptors) and ion channels (large conductance Ca2+ -activated potassium channels, or BK channels) in systemic arteries and veins, especially with regard to how venous ion channel dysfunction contributes to cardiovascular disease. Approaches in my studies include: 1) Measurement of vascular receptor and ion channel function in situ, this is a very integrative approach to study the receptor and ion channel function in blood pressure regulation; 2) Measurement of vascular receptor and ion channel function and molecular biological techniques in vitro, which allow to study the signal transduction in regulation of receptor and channel function; 3) Patch clamp methods to study directly ion channels in vascular smooth muscle cells. It is important to relate changes in ion channel function at the single channel level to changes in vascular function in hypertension.
Selected
Publications
Xu H, Fink GD, Galligan JJ. Increased sympathetic venoconstriction and reactivity to norepinephrine in mesenteric veins in anesthetized DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol 293:H160-168, 2007.
Xu H, Jackson WF, Fink GD, Galligan JJ. Activation of BK Channels by Tempol in Arterial Smooth Muscle Cells from Normotensive and DOCA-salt Hypertensive Rats. Hypertension, 48, 2006 (In press)
Xu H, Bian X, Watts SW, Hlavacova A. Activation of Vascular BK Channel by Tempol in DOCA-salt Hypertension. Hypertension 44: 1154 – 1162, 2005.
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