Student Background/Interests
I received my bachelor's degree in Physiology at Michigan State University
in 2002. I'm currently working with Drs. P.S. and Sheba MohanKumar on
obesity project. The research focus is on the relationship between leptin,
an adipocyte-derived hormone, norepinephrine, and HPA (stress) axis. Since
many years ago, by using a number of different in vivo and in vitro rat
models, Drs. Mohankumar have focused on and have generated a paradigm
between leptin and HPA axis, and norepinephrine as an intermediary. For
example, in fasting rats or streptozocin-induced diabetic rats, the stress
axis and norepinephrine (a potent stress axis activator) are elevated. When
leptin is given either ip or icv, the norepinephrine concentration in PVN of
hypothalamus and the stress activity is normalized to the control level.
What's very intersting is that in obese subjects (both humans, non-human
primates, or rodents), the stress axis is dysregulated in spite of
hyperleptinemia. It's possible that in obese subjects the
leptin-norepinephrine-HPA axis circuitry is not intact that might predispose
them of obesity development. Currently I'm investigating the role of and
the relationship between leptin and HPA axis and norepinephrine in
diet-induced obesity (DIO) and diet-resistant (DR) rats.
Poster Presentations
Shin AC, MohanKumar SM, Zhao H, Haywood JR, Fink GD, MohanKumar PS. Functional changes in the HPA axis of diet-induced obese (DIO) rats after high-fat diet exposure, ENDO meeting, Boston, Massachusetts, June 2006
Shin AC, MohanKumar SM, Zhao H, Haywood JR, MohanKumar PS. Development of diet-induced obesity: Possible role for IL-1ß, Society for Neuroscience Meeting, Washington D.C., November 2005
Shin AC, MohanKumar SM, Zhao H, Haywood JR, MohanKumar PS. Possible role for the neuroendocrine system in the development of obesity in diet-induced obesity rat model, NAASO meeting, Vancouver, Canada, October 2005.
Shin AC, MohanKumar SM, Dhurandhar NV, MohanKumar PS. Adipogenic human adenovirus Ad-36 modulates rat-HPA axis, North American Association for the Study of Obesity (NAASO), Las Vegas, NV, November 2004
Oral Presentations
Shin AC, MohanKumar SM, Zhao H, Haywood JR, Fink GD, MohanKumar PS. Hypothalamo-pituitary-adrenal dysfunction in diet-induced obese rats: possible role for defective leptin signaling, Society for Neuroscience Meeting, Atlanta, Georgia, October 2006
Shin AC, MohanKumar SM, Zhao H, Haywood JR, Fink GD, MohanKumar PS. Hypothalamo-pituitary-adrenal dysfunction in diet-induced obese rats: possible role for defective leptin signaling, Phi Zeta Research Day, College of Veterinary Medicine, MSU, October 2006
Shin AC, MohanKumar SM, Zhao H, Haywood JR, MohanKumar PS. Possible role for the neuroendocrine system in the development of obesity in diet-induced obesity rat model, Phi Zeta Research Day, College of Veterinary Medicine, MSU, October 2005
Shin AC, MohanKumar SM, Dhurandhar NV, MohanKumar PS. Infection with Ad-36 suppresses the rat hypothalamo-pituitary-adrenal axis, Phi Zeta Research Day, College of Veterinary Medicine, October 2004
Shin AC, Berkel R, MohanKumar SM, MohanKumar PS. The chronic effects of estrogen on the induction of inducible nitric oxide synthase (iNOS) in the brain McNair/SROP Meeting, Michigan State University, East Lansing, MI, August 2001
CIC SROP Conference, Pennsylvania State University, Philadelphia, PA, July 2002
Selected Publications
Click Here to see all Publications by Andrew
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Andrew
Shin