Neuroscience Program Seminar

Speaker

Brendon Watson

University of Michigan

Title

Neural oscillations, brain states and firing dynamics

Abstract

The brain travels through varying oscillatiory states as animal behavior varies, including and especially changes in sleep-wake status. Sleep is thought to mediate both mnemonic and homeostatic functions. However, the mechanism by which this brain state can simultaneously implement the 'selective' plasticity needed to consolidate novel memory traces and the 'general' plasticity necessary to maintain a well-functioning neuronal system is unclear. Recent findings show that both of these functions differentially affect neurons based on their intrinsic firing rate, a ubiquitous neuronal heterogeneity. Furthermore, they are both implemented by the NREM slow oscillation, which also distinguishes neurons based on firing rate during sequential activity at the DOWN→UP transition. These findings suggest a mechanism by which spiking activity during the slow oscillation acts to maintain network statistics that promote a skewed distribution of neuronal firing rates, and perturbation of that activity by hippocampal replay acts to integrate new memory traces into the existing cortical network.

 

Hosts

Dr. Mark Reimers

Location

Thursday, November 1, 2018 at 12:30pm

1425 BPS

 

This seminar is also available for viewing in room 1102 Grand Rapids Research Center